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inhaled colistimethate sodium  (ProMIS Neurosciences)

 
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    ProMIS Neurosciences inhaled colistimethate sodium
    Inhaled Colistimethate Sodium, supplied by ProMIS Neurosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/colistimethate+sodium/colistimethate+sodium/pm40101950-26-4-1
    Average 90 stars, based on 1 article reviews
    inhaled colistimethate sodium - by Bioz Stars, 2026-09
    90/100 stars

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    Infection:

    Article Title: Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects.
    Article Snippet: .. A phase III trial, PROMIS-I, suggested a clinical benefit of colistimethate sodium delivered via inhalation in patients with bronchiectasis and P. aeruginosa infection, although this effect was not replicated in PROMIS-II, which was affected by the COVID-19 pandemic and prematurely terminated [76–78]. ..

    Article Title: Pulmonary Delivery of Antibiotics to the Lungs: Current State and Future Prospects
    Article Snippet: .. A phase III trial, PROMIS-I, suggested a clinical benefit of colistimethate sodium delivered via inhalation in patients with bronchiectasis and P. aeruginosa infection, although this effect was not replicated in PROMIS-II, which was affected by the COVID-19 pandemic and prematurely terminated [ , , ]. ..

    other:

    Article Title: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
    Article Snippet: Findings 377 patients were randomly assigned in PROMIS-I (177 to colistimethate sodium and 200 to placebo; in the modified intention-to-treat population, 176 were in the colistimethate sodium group and 197 were in the placebo group) between June 6, 2017, and April 8, 2020.

    Article Title: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
    Article Snippet: In PROMIS-II there were 72 (47%) patients in the colistimethate sodium group with a total of 111 exacerbations.

    Article Title: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
    Article Snippet: In PROMIS-I, statistically significant improvements with colistimethate sodium versus placebo were also observed for quality of life (St George’s Respiratory Questionnaire total score), P aeruginosa density, annual rate of severe exacerbations, and time to first severe exacerbation.

    Article Title: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
    Article Snippet: In PROMIS-II, 123 (81%) patients in the colistimethate sodium group and 104 (77%) patients in the placebo group had at least one TEAE and most were mild or moderate in 8 www.thelancet.com/respiratory Published online September 10, 2024 https://doi.org/10.1016/S2213-2600(24)00225-X severity (table 4).

    Article Title: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
    Article Snippet: Given the results of PROMIS-I, there was a less than 1 in 2000 chance of PROMIS-II not showing a statistically significant benefit of colistimethate sodium.



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